High serum total bilirubin is commonly found in hemolytic disease, liver disease, bile duct obstruction, physiological factors, etc. According to the cause of the disease, we can choose life regulation, drug treatment, surgical treatment, dietary regulation, etc. 1. Hemolytic disease: such as autoimmune hemolysis, hereditary spherocytosis, etc. Red blood cells are destroyed in blood vessels, resulting in increased destruction of red blood cells, leading to increased serum total bilirubin. Generally, mild hemolysis can be treated without treatment. If the symptoms are serious and obvious jaundice occurs, glucocorticoid, such as prednisone, can be chosen for treatment; if conservative treatment is ineffective, splenectomy can be chosen. 2. Liver disease: such as hepatitis, fatty liver, cirrhosis, etc., bile synthesis and secretion disorders can lead to increased serum total bilirubin. If the symptoms are mild, the patient can improve his lifestyle, quit drinking and eat low-fat diet, etc. In addition, liver-protecting drugs, such as silymarin, can be used; liver transplantation can be considered for severe cirrhosis. 3. Bile duct obstruction: If stones or tumors compress the common bile duct, bile can not be discharged smoothly, resulting in increased serum total bilirubin. Mild elevation can be observed clinically or ursodeoxycholic acid can be used to lower the bilirubin; severe obstruction and serious elevation of bilirubin should be treated surgically. 4. Physiological factors: If the total bilirubin is elevated due to physiological factors such as irregular diet, it is recommended to eat a regular diet, consume more low-fat food and pay attention to appropriate exercise. In short, the serum total bilirubin is high, should consult the doctor in time, to clarify the cause of the disease, the drug under the guidance of the doctor to use.