High enzymes in the liver are mainly considered to be caused by medical and surgical diseases. Physiological causes, including staying up late, irregular lifestyle, overeating, high-fat eating, and insomnia can also cause mildly high liver enzymes; surgical causes include hepatobiliary stones, biliary tract infections, biliary obstruction, cirrhosis, biliary stasis, and benign and malignant liver tumors can cause high liver enzymes. In internal medicine, fatty liver, alcoholic liver, liver fibrosis, viral hepatitis, drug-related liver damage, liver bile, and autoimmune liver disease can all cause elevated liver enzyme profiles. Sometimes it is necessary to combine various examinations to clarify, and then take targeted treatment to achieve the role of liver preservation, liver protection and maintenance of normal liver function.