The efficacy of Nateglinide is hypoglycemia, and the side effects include hypoglycemia, allergic reaction, liver function abnormality, gastrointestinal reaction and so on. Naglinide is an amino acid derivative, commonly used clinical dosage forms include tablets, dispersible tablets, capsules, belongs to oral antidiabetic drugs, clinically used in the treatment of type 2 diabetes mellitus. The common clinical side effects of this drug are hypoglycemic symptoms, such as shivering, dizziness, increased appetite, sweating, palpitations (rapid heartbeat, often accompanied by panic), etc. A small number of patients may also have liver function abnormalities such as increased liver enzymes or allergic reactions such as rashes and itching, as well as gastrointestinal reactions such as abdominal pain, indigestion and diarrhea, etc. If any of the above discomforts occurs during the administration of the drug, and when the symptoms become more severe, timely medical attention should be sought. It should be noted that the use of Nateglinide is prohibited for those who are allergic to any components of the drug, pregnant women, lactating women, patients with type 1 diabetes mellitus, patients with diabetic ketoacidosis, and patients with type 2 diabetes mellitus who are not satisfactorily treated with sulfonylurea hypoglycemic drugs are not suitable for the use of this drug. Patients should follow the doctor’s instructions to use any preparation of Naglinumab, and avoid blindly using the drug on their own, so as not to affect the condition, or side effects.