When acne, also known as acne vulgaris, is smothered in the skin, it is considered to be acne with significant keratinization. Keratinolytic medications, such as retinoids, can be used to reduce hyperkeratinization of the epithelial cells of the hair follicles and the adhesion of the stratum corneum, thereby reducing the formation of acne and accelerating its discharge. Commonly used retinoids include adapalene gel, tazarotene, and isotretinoin, which are usually applied topically in small amounts once a night and can effectively control keratinized acne. If there are more lesions, you can also give oral retinoids, such as isotretinoin soft capsules or vitamin capsules. Note: Pregnant-age women should preferably not take them and need contraception after using the medication. In severe cases, you can also go to the hospital and perform chemical peeling treatment with fruit acids.