Demyelination can be categorized into peripheral nervous system demyelination and peripheral nervous system demyelination, and clinical symptoms include muscle weakness and sensory abnormalities. Demyelination of the peripheral nervous system can be seen in Guillain-Barre syndrome, manifested as muscle weakness, sensory deficits in the limbs, and in severe cases, respiratory paralysis. Central demyelination can be seen in multiple sclerosis, manifested as limb weakness, and different parts of the involvement, the performance is different, such as the involvement of the eye, can be manifested as nystagmus, vision loss, ataxia, etc.; if the involvement of the limbs, the limbs are weak, but also sensory deficits, such as numbness, pins and needles sensation. Some of them are also accompanied by mental symptoms, such as mania. If demyelination is considered, it is recommended to seek medical treatment as early as possible and standardize the diagnosis and treatment under the guidance of professional physicians.