Symptoms of mad cow disease in humans are manifested in the physical and mental aspects of the disease. Mad cow disease, or Crohn’s disease, is a subacute progressive neurological lesion caused by prions (a protein), transmitted through the digestive system (eating meat from infected animals), and is a new zoonotic infectious disease. 1. Early symptoms: mental changes such as insomnia, loss of interest, fatigue, loss of concentration, impaired cognitive/memory function may occur, and the characteristic 1433 protein may be detected by lumbar puncture of the cerebrospinal fluid. 2. Intermediate symptoms: At this point, cognitive function/disorientation is further aggravated and dementia (severe cognitive impairment) occurs, with varying degrees of motor function impairment. Parkinson’s disease-like symptoms such as resting tremor and muscle tension may be present, as well as acute dystonia, dyskinesia, slurred speech and ataxia. 3. Late symptoms: In this stage, there is inactive muteness, speech is severely impaired, and no voluntary movements are made. Eventually, death may occur due to lung infections, pressure sores, and so on. When Mad Cow Disease is suspected, timely consultation and standardized treatment are needed to avoid delay.