The skull is one of the hardest bones in the body and plays an important role in protecting the brain tissue inside the skull and maintaining the intracranial environment. However, cranial defects occur in life due to various factors, such as car accidents, mechanical injuries, falling objects, diseases, etc. Once skull defect brings great harm to patients’ health and psychology, because long-term skull defect will cause depression or bulge in some patients, and cause various complications that seriously threaten patients’ health, and also affect patients’ aesthetics and bring trauma to patients’ psychology. Without the protection of the skull to the brain tissue, even without the stimulation of external conditions, the human body’s own scalp and hair will spread, contact, and cover the brain tissue directly, and the brain tissue will be displaced with the change of body position for a long time, resulting in the change of blood circulation in the brain, or due to the adhesion displacement of the scalp and dura mater, the subarachnoid space disappears, the cerebral cortex perfusion decreases, and the softening foci of the brain tissue under the bone window increase, which can form traumatic cysts , cerebral penetration malformation, ventricular asymmetry, etc. The most direct manifestation is that patients have headache and dizziness, fear of sun and noise, not only have low self-esteem, depression and other psychological shadows, but also may cause memory loss, inattention and so on. Therefore, cranial bone repair is performed not only for the aesthetics of the patient’s head, but also for the health of the patient’s life. At present, we use PEEK cranial bone repair, using the highest affinity with human bone bionic material, three-dimensional reconstruction highly restored cranial bone structure, so that the damaged parts and the original bone window fit beautifully, not only the appearance of identical, but also can accelerate the development of bone healing, is worthy of the patient’s pro-visiting better repair materials.