In the middle of the night, the pain in the anus will be relieved naturally, in addition to eating spicy and stimulating food, mostly consider perianal abscess, anal fissure, rectal cancer and other diseases. 1. Dietary factors: eating too spicy and stimulating food at night, through the intestinal digestion and transportation, will also stimulate the anus, the formation of pain in the anus. 2. Perianal abscess: Perianal abscess belongs to infectious diseases, mostly accompanied by anal swelling, pain and other uncomfortable symptoms, it is generally recommended to consult the doctor in time and be treated with surgical incision and drainage. 3. Anal fissure: anal fissure belongs to a kind of anal injury, mostly due to feces or foreign body scratches. Because of the obvious pain in the body at night, it is self-conscious about the pain in the middle of the night. 4. Rectal cancer: Intestinal tumor may stimulate the mucous membrane infection, resulting in anal distension and pain, or the tumor oppresses the intestinal tract resulting in the inability to have normal defecation, which may also cause anal pain. It is recommended to go to the hospital in time when anal pain occurs, so as to clarify the condition and give reasonable treatment to avoid delaying the aggravation of the condition.