What is the best medicine to take for anal pain, according to the cause of anal pain caused by the patient, give symptomatic treatment. If the pain is caused by mixed hemorrhoids, the patient can control the diet, abstain from spicy food, give potassium permanganate 1:5000 sitz bath, or take oral Mizarin tablets to reduce the swelling and other symptomatic treatment, the symptoms can be relieved. If the patient’s anal pain is caused by perianal abscess or anal fistula, the patient needs to undergo surgery to remove the abscess and the symptoms can be relieved. If the patient’s symptoms of perianal abscess are mild, cephalosporins can be given to control the infection and the symptoms can be relieved significantly. If the anal pain is caused by rectal tumor or rectal polyp, it is suggested that the patient should go to the local hospital to improve the colonoscopy, and if necessary, surgery should be performed to remove it. If the anal pain is caused by advanced malignant tumor of rectum and cannot be treated by surgery, it can be relieved by a variety of comprehensive treatment measures such as chemotherapy and radiotherapy.