Microglobulin in urine is too high, mild elevation may be physiological; severe elevation is generally considered to be pathologic. 1. Slightly elevated: it may be related to dietary factors, environmental factors, nerves and mental factors. Consuming large amounts of protein-rich food, too cold weather and strenuous exercise may cause high urine microglobulin. 2. Severe elevation: it may be caused by damage to the glomerular filtration membrane, such as nephrotic syndrome and glomerulonephritis, etc., which will lead to a large amount of microglobulin in the blood, which enters the tubules through the glomerular filtration membrane and enters the urine. If the condition of high microglobulin is more serious, patients are recommended to go to regular hospitals for further examination and treatment.