Itchy blisters on the palms of the feet may be caused by tinea pedis, herpes sweating, eczema and other diseases, which can be treated with general therapy and medication. 1. Tinea pedis: for tinea pedis caused by long itchy blisters on the palms of the feet, daily need to keep the local dry hygiene. Patients can use topical imidazole creams such as econazole and isoconazole, which have antibacterial effects. Can also be used externally amorolfine, cyclopyrrolidine and other ointments, with bactericidal effect. 2. Sweat herpes: If the blisters on the palms of the feet are itchy due to sweat herpes, wear loose and comfortable shoes and socks daily. Patients can follow the doctor’s instructions to take oral antihistamine drugs such as benadryl and loratadine, which can relieve itching. You can also use topical mometasone furoate treatment. 3. Eczema: For eczema caused by long blisters on the palms of the feet itchy, daily need to avoid contact with the stimulus, do not scratch the affected area. Patients can follow the doctor’s instructions to use dexamethasone, tretinoin and other glucocorticoid creams, with anti-inflammatory effect. There are many reasons that lead to itchy blisters on the palms of the feet, it is recommended that the patient go to the hospital, after clarifying the cause of the disease treatment.