Gastroesophageal reflux recurrence after treatment is recommended to inhibit gastric acid secretion, promote gastric dynamics, protect the gastric mucosa and other drug therapy, the choice of drug therapy should pay attention to the full amount, the full course of treatment, to reduce the chances of recurrence. 1. Inhibit gastric acid secretion: commonly used drugs are omeprazole, lansoprazole, epprazole and so on. 2. Promote gastric motility: If the effect of purely using drugs to inhibit gastric acid secretion is not obvious, it is recommended to add drugs to promote gastric motility, such as: domperidone, mosapride and so on. 3. Protect the gastric mucosa: patients suffering from GERD will cause irritation to the gastric mucosa and esophageal mucosa, and it is recommended to use medications to protect the mucosa, such as: magnesium aluminum carbonate. In addition to the above medications, some patients suffering from GERD may also be caused by anxiety and depression, and it is recommended to add anti-anxiety and depression medications, such as: paroxetine, etc. For patients suffering from GERD, relapse occurs after treatment, and it is recommended to go to the hospital first when medication is used again, and choose the appropriate medication for treatment according to the patient’s specific situation after the doctor’s interview. During the treatment period, more attention must be paid to the fact that the medication should not be missed or taken for too short a period of time, and at the same time, more attention should be paid to the intervention in daily life to reduce the recurrence rate.