Causes of cough and asthma in late stage of lung cancer include invasion of trachea, bronchus and pleura by lung cancer cells, obstruction of airway by lung cancer tumor, and combination of obstructive pneumonia in lung cancer patients. 1. Lung cancer invades trachea, bronchus or pleura and causes local mucous membrane congestion and damage, which leads to exuberant mucous membrane secretion and irritation of secretion, resulting in coughing and wheezing symptoms. 2. Late-stage lung cancer with large tumors will directly cause obstruction of airways such as trachea and bronchus, which will cause more serious symptoms of coughing and wheezing. 3. Due to the obstruction or compression of airway by tumor, the secretion in airway cannot be excreted in time, or due to low immunity of patients, it is very easy to be complicated with obstructive pneumonia, and the symptom of coughing and wheezing will often appear in clinic. Patients with coughing and wheezing in the late stage of lung cancer need to consult doctor in time to further clarify the cause of the disease and target treatment.