Cranial defect is a common disorder in neurosurgery clinic, many accidents in life may cause damage to the skull. Like traffic accidents, production safety accidents, falling from height, throwing objects from height, fighting, etc. may cause craniocerebral injury, cranial defects, as well as some of its own craniocerebral diseases such as cerebral hemorrhage, brain tumors, etc. require craniotomy treatment can not be instantly returned to the flap of the bone and the remaining cranial defects. So what do these patients with cranial defects need to pay attention to? This question is relatively broad, patients with cranial defects need to pay attention to a lot of places, here briefly say a few points, not necessarily comprehensive. First of all, patients should pay attention to living and living, try to avoid strenuous exercise, especially to avoid the defective parts of the outside world by the impact of the bump, it is easy to injure the brain tissue; second, patients need to pay attention to the diet, should ensure adequate nutrition, while eating a light diet, to avoid too much grease; There is also, pay attention to patients with cranial defects of the psychological attention and guidance, cranial defects patients are very prone to have inferiority complexes and even depressed mood! The family should communicate with the patient more often, and if necessary, professional psychological counseling; finally, the most important point is to carry out cranial bone repair in a timely manner. Cranial repair is a routine surgery in neurosurgery, the technology is very mature, but to really do a good job, it is not simple, you need to choose a good repair material, but also need senior, experienced neurosurgeons to complete. Let’s talk about the material first, at present, most of the general hospitals in clinical use of cranial bone repair material is mainly titanium mesh, and this metal material also has some defects and shortcomings. For example, the clinical use of titanium mesh cranial bone repair may be infected with postoperative rejection, wear and tear of the scalp, material exposure, collapse and deformation, fear of cold and heat, affecting the CT resonance examination, molding effect is not ideal and so on. At present, there is a more excellent performance of the new material – polyether ether ketone PEEK material, this material in the hardness, strength, elasticity, thermal insulation, stability, histocompatibility, radiation transmissibility, plasticity and so on are comparable to the autologous skull, can be achieved ideal cranial bone repair effect. Besides, although cranial bone repair surgery is a routine surgery, it is also a great test of physician’s skills, requiring the operator to be very familiar with the anatomical structure of the head and face, and need very fine operation to achieve a good reset and protection of various tissues such as nerves, blood vessels, muscles, etc., and requiring the operator to have a strong psychological quality and resilience, and to properly deal with all kinds of situations that may occur during the operation, and so on. Our team applies advanced polyether ether ketone PEEK as the cranial bone repair material, and constantly carries out technical improvement and material optimization design, and currently has 4 technical innovations, and also innovatively introduces the concept of cosmetic plastic surgery, so as to comprehensively carry out the PEEK cranial bone repair and plastic surgery, which can achieve the organic unity of anatomical integrity, perfect function, and aesthetically pleasing appearance.