Hard bumps at the root of the penis that are painful to touch may be caused by folliculitis, genital herpes, sebaceous cysts and other diseases. It is recommended to go to the hospital in time to take appropriate treatment measures after a clear diagnosis. 1. Folliculitis: If the skin follicles at the root of the penis have fungal or bacterial infections that cause an inflammatory reaction, it will result in bumps that protrude from the skin with painful symptoms. At this time you need to keep the skin clean and hygienic, the diet should be light, you can use saline rinse, wipe iodine povidone disinfection, in the doctor’s guidance, topical antibiotic ointment treatment, such as metronidazole gel, mupirocin ointment and other drugs. Serious cases can also be combined with oral antibiotics, such as ornidazole tablets, cefuroxime tablets and so on. 2. Genital herpes: mainly due to herpes simplex virus infection, easy to cause the skin around the genitals appear small blisters, ulceration, vesicles, etc., the root of the penis may also appear pimples, the beginning of small blisters, with the progress of the condition of the blisters broken to form vesicles, oozing fluid or pus secretion, accompanied by pain symptoms. At this time, you need to actively anti-viral treatment, such as oral acyclovir, vasiclovir and other drugs, topical acyclovir ointment and so on. In addition, if the sexual partner is also sick, should be treated at the same time. 3. Sebaceous cysts: Sebaceous cysts are mainly formed when sebum accumulates due to the blockage of sebaceous gland openings, and if infection occurs, it will be accompanied by pain, i.e., the root of the penis grows a pimple with symptoms of pain. At this time, you can first according to the results of drug sensitivity antibacterial treatment, to be given after the infection control surgery to remove the cyst treatment.