Gray nails do not necessarily require nail extraction. Except for the special cases that need to remove the diseased nail, such as thick nail plate, other cases through surgical nail extraction has been rarely used, because nail extraction can not eradicate onychomycosis, but also may cause nail plate deformation. Gray nails are usually treated with topical medication or systemic medication. 1. Topical drug treatment: commonly used in distal lateral subnail type or white superficial damage, treatment should first use nail file or knife, as far as possible to remove the diseased nail. Then the affected area should be treated with topical amorolfine. 2. Systemic medication: Itraconazole and Terbinafine are commonly used. The course of treatment for nails is usually six to eight weeks for terbinafine and twelve to sixteen weeks for toenails. Alternatively, intermittent shock therapy with itraconazole can be used, which typically takes two to three sessions for nails and three to four sessions for toenails. The use of topical medications in conjunction with oral medications can be effective in improving the efficacy of the treatment. After the appearance of gray nails, should go to the regular medical institutions, the use of drugs need to follow the doctor’s instructions, so as not to delay the condition.