Ki67 positivity rate of 40% is more serious, it is recommended to refer to the tumor type and local pathological laboratory center for comprehensive evaluation.
Ki67 antigen is one of the indicators of tumor proliferative activity.Ki67 positivity rate refers to the proportion of Ki67 positively expressing cells to the total number of tested cells.The higher the Ki67 positivity rate is, the higher the proliferative activity of the tumor is, and the tumor is poorly differentiated, highly malignant, and prone to recurrence and metastasis.
According to the Ki67 positivity rate, it can be categorized as high, low expression and negative (-), weak positive (+), moderate positive (++), strong positive (+++).
Different tumor types and different testing methods will have different grading thresholds. Generally 20-30% is the high and low expression cut-off value for breast cancer, <10% is negative for gastric cancer and cervical cancer, 10-25% is (+), 26-50% is (++), and >50% is (++++).
Ki67 positivity rate of 40% generally belongs to moderate positivity or high expression, indicating that the tumor proliferation is more active and the prognosis is poor. However, it is still recommended that patients should refer to the results of the report of the pathological laboratory center of the local hospital for judgment, and also need to consider the pathological type and stage of the tumor, etc., and should consult the doctor in time to choose the appropriate treatment plan.