Quadruple generally refers to the quadruple treatment method after Helicobacter pylori infection, after eight days of eating the stomach is still difficult, it may be that the course of treatment has not yet arrived, and the effect of the drug has not yet been up. It may also be affected by the side effects of antibiotics. In the clinic, the recommended course of quadruple therapy is 14 days, eight days of time may be the drug efficacy has not come out, the effect is not yet obvious, so the symptoms of gastric distress have not disappeared. Quadruple therapy generally includes antibiotics such as amoxicillin, furazolidone and other antibiotics, and the dosage is large, because these drugs will form a certain stimulation of the patient’s gastric mucosa, it may be difficult to stomach. Antibiotics need to be taken after meals, and if necessary, patients need to communicate with their doctors in time to take a change of medication. Patients should avoid smoking, drinking and other behaviors during the period of medication, and ensure sufficient sleep, so as not to aggravate the condition.