Interstitial changes can be treated with anti-infective therapy, because interstitial changes in local organs or tissues of the organism are generally pathological changes due to persistent local inflammatory stimulation caused by infection with bacteria, viruses, and harmful microorganisms. Treatment with specific antibiotics can eliminate pathogenic bacteria and control inflammation diffusion, and glucocorticoids such as prednisolone, betamethasone and clobetasol propionate can be used, which have good preventive and restorative effects on organ damage caused by local interstitial lesions. In addition, the actual symptoms of the patient should be combined with antipyretic, antihistamine, cough and antispasmodic drugs for combined treatment. The specific treatment plan needs to be checked at a regular hospital to confirm the specific cause of the disease before symptomatic treatment.