The sex hormones commonly used in clinical practice are estrogenic drugs, progestinic drugs and androgenic drugs, which can help the body to supplement the required sex hormones, but long-term use of sex hormones may lead to endocrine disorders, skin damage and so on. 1. For premenopausal women, because of exogenous supplementation of sex hormones, the function of the hypothalamus-pituitary endocrine axis will be inhibited, long-term use of sex hormone drugs, the body may not be able to independently secrete and regulate sex hormones caused by endocrine dysfunction, premenopausal women may be manifested as irregular menstruation or even amenorrhea, but also may lead to vascular thrombosis disease, obesity, lower limb edema and so on. 2. For postmenopausal women, long-term use of sex hormone drugs may cause irregular vaginal bleeding, uterine hypertrophy, frequent urination and other symptoms, and under the long-term stimulation of hormones will increase the chances of endometrial cancer, breast cancer, thrombotic diseases. Sex hormone drugs have strict indications and contraindications, it is recommended to go to the hospital in a timely manner, the use of medication please follow the doctor’s instructions.