How thick is the lining of the uterus? What is the pattern of changes with menstruation? I believe many women have such questions, so follow our footsteps to learn more about it! Why does the endometrium thicken? Exogenous estrogen 1, estrogen replacement therapy: perimenopause or postmenopause, due to estrogen deficiency and menopausal syndrome, while there may still be osteoporosis, abnormal lipid metabolism, cardiovascular changes, and even changes in brain cell activity. Therefore, ERT is gradually being widely used and has achieved good results. However, ERT with estrogen alone can stimulate endometrial hyperplasia. One year of estrogen alone can cause endometrial hyperplasia in 20% of women (Woodruff 1994), and the application of ERT is often continuous for years, even until the end of life, for a long time. 2. Application of tamoxifen: Tamoxifen has anti-estrogenic effect, so it is used for postmenopausal patients with advanced breast cancer. Under the condition of low estrogen, TAM also has a weak estrogen-like effect, so long-term use of TAM can also cause endometrial hyperplasia. Treatment of endometrial atypical hyperplasia should first be clearly diagnosed and the cause of the atypical hyperplasia should be identified, whether there are polycystic ovaries, functional ovarian tumors or other endocrine dysfunctions. Those with any of these conditions should undergo targeted treatment. At the same time, symptomatic treatment of endometrial atypical hyperplasia can be started with either pharmacological or surgical treatment. The choice of these two treatment options should vary according to age, type of endometrial hyperplasia, and fertility requirements. Too thin endometrium leads to infertility The thickness of the endometrium varies at different times of a woman’s menstrual cycle, mainly due to the influence of hormonal secretion at different times. If the thin endometrium is caused by factors such as miscarriage, it can have a great impact on a woman’s pregnancy. There are many reasons for endometrial thinning, the most common ones are: 1, endocrine disorder Women’s emotions have a great impact on the endometrium, long-term nervous and worried psychology often leads to endocrine disorder, which affects the thickness of the endometrium. 2, abortion scraping on the endometrium caused damage to the endometrium is divided into three layers, the uppermost layer is peeled off every month, the middle layer and the bottom layer is not peeled off, if the middle layer is damaged, the impact is not big, if the bottom layer is damaged, then the consequences will be more serious. 3, endometrial lesions such as endometrial polyps, endometrial cancer, etc. A thin endometrium can make it difficult for a fertilized egg to be laid, which can lead to infertility.