There is no authoritative books and documents that record “the strongest remedy for tonifying essence and marrow”. Clinical treatment for deficiency of kidney essence and insufficient bone marrow is often carried out by adding or subtracting Seven Fortune Drink and Zuo Gui Wan. The specific medication should follow the doctor’s prescription. 1. Seven Fortunes Drink is composed of ginseng, Radix Rehmanniae Praeparata, Radix Angelicae Sinensis and other medicines, which can tonify the kidney and benefit the marrow, fill in the essence and nourish the spirit, and is mainly used for treating dementia with deficiency of heart, spleen and kidney qi, and deficiency of the medulla oblongata, which is characterized by dizziness and dizziness, insomnia, excessive dreaming, and loss of memory and computation power. The adverse reactions and contraindications of this drug are not clear. 2. Zuo Gui Wan: composed of Chinese yam, Radix Rehmanniae Praeparata, Cornu Cervi Pantotrichum and other medicines, with the effect of benefiting essence and filling up the marrow, nourishing kidney yin, it has a therapeutic effect on the loss of essence and marrow caused by kidney yin and kidney essence deficiency, with symptoms such as lumbar and knee soreness and tenderness, spermatorrhea and urinary emission, impotence of tendons and bones and insomnia and excessive dreaming. Caution should be exercised in cases of loose stools (thin and unformed feces) due to spleen deficiency. Specific medication should be taken under the guidance of a physician, do not take medication on your own to avoid delaying the condition.