Total protein is the sum of albumin and globulin. When both albumin and globulin are low, the following diseases are usually considered: 1. wasting diseases: malignant tumors can cause a lot of consumption, which can lead to low total protein if the intake is insufficient; 2. liver diseases: the liver is the main place for synthesizing albumin. If albumin is excessively low and globulin is normal instead, and there are abnormal coagulation mechanisms, including platelet reduction, consider the possible existence of liver diseases. including reduced platelets, consider the possibility of liver disease, such as cirrhosis; 3, other diseases: such as the presence of protein-losing enteropathy, massive diarrhea, may also lead to a decrease in total protein, which is also dominated by a decrease in albumin. Nephrotic syndrome may also lead to a decrease in protein, due to excessive loss of protein in the urine, which leads to a decrease in total protein and albumin. Patients with the above mentioned diseases should be seen in a timely manner so that serious diseases can be ruled out.