Low acrosomal enzymes should be examined in a regular hospital and receive systematic treatment. The time to return to normal is usually 1-3 months for mild cases and may take 3-6 months for severe cases. Acrosomal enzymes are found in the inner membrane of the sperm acrosome and the equatorial membrane, usually in an inactive form. Acrosomal enzymes are activated when the head of the sperm enters the zona pellucida. Acrosomal enzymes are indispensable in the fertilization process and are able to hydrolyze the zona pellucida glycoproteins, which allow the sperm to pass through the egg globule, and then through the zona pellucida to allow fusion of sperm and egg. If the acrosomal enzyme is low, it will result in low sperm motility and will not easily combine with the egg to form a fertilized egg. This means that the sperm’s ability to fertilize the egg is weak, and it usually requires systematic treatment to recover. Therefore, it takes 1-6 months for low acrosomal enzymes to return to normal after active treatment with doctors. In addition to regular treatment, patients with low acrosomal enzymes should ensure a happy mood, sufficient sleep, and avoid smoking, drinking and staying up late during the conditioning process. At the same time to do more aerobic exercise to improve the body’s immunity, pay attention to a reasonable diet and protein intake.