Mesenchymal tumors of the gastrointestinal tract are a group of tumors originating from the mesenchymal tissue of the gastrointestinal tract and account for the majority of mesenchymal tumors of the GI tract. As a relatively new concept, mesenchymal tumor should cover what was previously called “gastrointestinal smooth muscle tumor” or “gastrointestinal smooth muscle sarcoma”. However, the concept of gastrointestinal smooth muscle tumors or sarcomas as tumors of mesenchymal origin has not been excluded, except that in the current clinicopathologic diagnosis, these tumors account for only a small proportion of tumors of mesenchymal origin in the gastrointestinal tract. Therefore, we must now change the concept of gastrointestinal mesenchymal-derived tumors from one in which smooth muscle tumors predominate to one in which gastrointestinal mesenchymal tumors predominate. So which is the best treatment for gastric mesenchymal tumor? Lin Yaodong, Department of Surgery, Tianchang People’s Hospital The birth of comprehensive tumor therapy has made cancer treatment more diversified, and the survival of cancer patients does not only depend on radiotherapy and chemotherapy, but tumor treatment increasingly tends to a safer and greener treatment mode, which pays more attention to the quality of patients’ life while guaranteeing their treatment effect. The best treatment method for mesenchymal tumor: comprehensive treatment Comprehensive personalized treatment method is to apply the existing treatment means in a planned and reasonable way according to the patient’s body condition, pathological type, invasion scope and development trend of the tumor, in order to maximize the cure rate and improve the quality of survival. Our hospital adopts the joint consultation system of expert medical team for each patient, and designs the most scientific and comprehensive treatment plan according to the patient’s body condition, pathological type, stage and development trend of tumor, etc., and applies various effective multidisciplinary treatments in a planned and reasonable manner to obtain the best treatment effect at the most suitable economic cost and improve the patient’s survival quality to the greatest extent. It is the best treatment plan for tumors at this stage and is the basic principle of most tumor treatments. In order to avoid one-sidedness and reduce the mistakes in decision making, the comprehensive treatment of tumor should pay equal attention to the patient’s whole body condition and the specific characteristics of tumor. Comprehensive tumor treatment is not a simple combination of surgery, chemotherapy, radiotherapy, biological treatment and Chinese medicine treatment, but a planned, step-by-step and sequential individualized treatment process, which requires the effective collaboration of multiple disciplines such as surgery, radiotherapy and chemotherapy to complete successfully. Although the comprehensive treatment plan is not a fixed treatment model, it may be adjusted in the process of specific diagnosis and treatment with the gradual improvement of diagnosis and the difference of treatment effect.