The whitening of the mucosa of the middle esophagus may be due to physiological factors such as diet, or pathological factors such as esophagitis and esophageal leukoaraiosis. 1. Physiological factors: if the patient eats a lot of too hot, too spicy and other stimulating foods, or unclean diet, long-term alcoholism, smoking, etc., it will stimulate the mucosa of the esophagus, resulting in edema of the mucosa, which will make the patient’s mucosal whitening in the middle part of the esophagus. 2. Pathological factors: such as esophagitis, esophageal leukoaraiosis, etc., can also lead to congestion and edema of the esophageal mucosa, or even ulcers, etc., and whitening of the mucosa of the middle esophagus can also occur during endoscopic examination. This may be accompanied by nausea and vomiting, acid reflux, loss of appetite, and difficulty in swallowing. There are other causes of whitening of the mucosa in the middle esophagus, such as anemia, endocrine disorders, and systemic progressive sclerosis. When the patient endoscopy found that the mucosa of the middle esophagus whitening, it is recommended to consult a doctor in time to identify the cause of the disease and carry out targeted treatment to avoid delaying the condition.