A newborn’s generalized purple coloration after breastfeeding may be due to a condition such as tetralogy of Fallot. Tetralogy of Fallot includes right ventricular outflow tract obstruction, aortic riding, right ventricular hypertrophy, and ventricular septal defect. The clinical presentation is characterized by increased shortness of breath and cyanosis after activity, and hypoxic episodes after breastfeeding that manifest as paroxysmal dyspnea. Growth and development are generally delayed, and intellectual development may be slightly behind normal children. x-ray shows a boot-shaped heart with right ventricular and right atrial hypertrophy. Patients with tetralogy of Fallot should usually prevent infection and combat dehydration and complications. If the condition cannot be effectively controlled, timely surgical repair should be considered. Newborn babies after feeding the whole body purple, there may also be other reasons, it is recommended to go to the hospital in a timely manner, improve the examination to clarify the cause of the disease, under the guidance of the doctor to give targeted treatment or treatment.