The normal value of serum hyaluronic acid is (57±27) μg/L. Abnormal serum hyaluronic acid values can be a relatively sensitive indicator of the degree of liver fibrosis. Hyaluronic acid is secreted by hepatic stellate cells, constitutes an important component of glycosaminoglycans, and is metabolized in the liver. In patients with liver disease, hepatic stellate cells are heavily activated and secrete excessive amounts of hyaluronic acid, causing their serum levels to rise. Elevated serum hyaluronic acid can be used as a sensitive indicator for early diagnosis of liver fibrosis. Acute and chronic hepatitis, cirrhosis, hepatocellular carcinoma and other long-term chronic liver injury can cause the occurrence of hepatic fibrosis, so that hyaluronic acid is elevated, and other diseases such as rheumatoid arthritis, diabetic nephropathy, lung cancer, idiopathic pulmonary fibrosis, hyperthyroidism protuberance and other diseases can cause serum hyaluronic acid to be elevated. Patients who find elevated serum hyaluronic acid during examination should seek timely medical treatment, improve the abdominal ultrasound, chest CT, thyroid function measurement and other examinations, actively treat the primary disease, and follow the doctor’s instructions for medication.