High-risk HPV58 infection usually requires a cervical TCT test, and follow-up treatment will be determined based on the test results. High-risk HPV is the main causative factor causing cervical intraepithelial neoplasia and cervical cancer, so a positive test for high-risk HPV58 is preferred and requires cervical TCT to rule out cervical intraepithelial neoplasia and cervical cancer. 1. If the TCT test is negative, high-risk HPV58 positive for simple HPV infection, for the young resistance is relatively strong, usually without special treatment, generally can be restored by themselves to negative, follow the doctor’s instructions to do regular review; and for the resistance is weak, you need to follow the doctor’s instructions to choose the XinFuNing, RuibeiSheng, etc., symptomatic drug treatment, or physical therapy such as laser, microwave, cryotherapy and so on, or physical therapy such as laser, microwave, cryotherapy, etc. 2. If the TCT test is positive, high-risk HPV58 positive for high-grade lesions, need to be considered in conjunction with the patient’s situation for surgical treatment, such as cervical conization. In addition, because high-risk HPV is contagious, it is recommended that sexual partners should be examined and treated together to detect and treat the disease as early as possible, and avoid coitus during the treatment period to reduce the spread of the virus.