Generalized wasting type refers to the body’s weight loss due to disease or certain factors, and it is wasting when it is more than 10% below the standard body weight (some authors believe that any body weight that is more than 10% below the standard body weight is considered as lean, and any body weight that is less than 20% above the standard body weight is called wasting). What are the causes of generalized wasting? 1, calorie a protein intake is insufficient Under normal circumstances, eating is the only way to ingest energy. Nutritional deficiency and wasting is mostly caused by insufficient calorie and protein nutrition. Insufficient calorie intake, first by the adipose tissue to provide energy, protein provides amino acids as a substrate for glycogen isomerization. Such as disasters, wars and poor areas of backward production, the calorie deficit is called wasting disease (Marimus), people show very obvious wasting, no edema; to protein intake is called Kwshior-kor disease, often with edema. 2.Hypothalamic Syndrome When the hypothalamus is damaged by various factors, the center of food baiting in the lateral nucleus of the abdomen (food-loving center) is damaged, and the center of satiety in the medial nucleus of the abdomen (anorexia center) is relatively excited and refuses to eat and anorexia, which leads to emaciation. 3.Oral, pharyngeal, laryngeal, esophageal, cardia lesions cause difficulty in swallowing, affecting eating and leading to wasting Oral inflammation, ulcers, injuries: such as riboflavin deficiency, leukosis caused by oral ulcers, inflammation, nicotinic acid amine deficiency caused by lingual inflammation, teeth and gum lesions. Pharyngeal and laryngeal inflammation, tuberculosis, cancer. Inflammation or stenosis of the esophagus, carcinoma of the esophageal cardia, achalasia or stenosis. Cerebral nerve palsy, bulbar palsy. Myasthenia gravis, polymyositis, systemic sclerosis and other esophageal muscle damage. 4, gastrointestinal diseases such as chronic gastritis, peptic ulcer, gastric cancer, pyloric stenosis. Incomplete intestinal obstruction, gastric resection, etc., often make the nutrient intake is insufficient and lead to wasting. 5, malignant tumors, wasting is often one of the main manifestations of malignant tumors. Causes of wasting may be: ① Lack of appetite is the main factor, especially due to anxiety and treatment reaction, which aggravates the lack of appetite. ② The rapid growth of tumor consumes energy; ③ Malignant tumors may produce a metabolic toxin, which reduces the glucose utilization rate of patients, increases the oxidative metabolism of free fatty acids, increases the isomerization of amino acids and lactate to glycogen, and increases the ineffective consumption of ATP. ④ Tumor secondary infection, hemorrhage, exudation, etc. make patients with middle and advanced malignant tumors more emaciated. 6.Chronic infections such as tuberculosis, schistosomiasis, typhoid fever, chronic septic infections and so on cause patients to obviously lack of appetite, fever increases energy consumption. The first symptoms of AIDS patients are emaciation, fatigue and fever. 7, the important organs of chronic disease or functional failure caused by wasting, such as heart failure to the liver and gastrointestinal congestion, edema, chronic lung and heart disease caused by tissue ischemia, hypoxia, severe liver disease, such as cirrhosis, portal hypertension caused by gastrointestinal stasis and edema, hepatic impairment caused by abdominal distension, nausea, or even vomiting, hypoproteinemia, renal failure caused by uremia, nausea, vomiting, lack of appetite, and so on, all of the above are due to the lack of appetite. Lack of nutritional intake leads to wasting. 8, the use of certain drugs often lead to lack of appetite and wasting, such as long-term use of antibiotics, sulfonamides for the treatment of various infectious diseases, long-term application of aminophylline, p-aminosalicylic acid. Amine chloride, estrogen, etc. can lead to epigastric distension, loss of appetite, thyroxine, amphetamine, etc. can make the metabolic rate increased significantly, the long-term application of laxatives affect the intestinal absorption function can lead to wasting. 9, anorexia nervosa patients due to emotional disorders in the state of food refusal, weight loss can be sharp.