The treatment principle of duodenal ulcer with upper gastrointestinal bleeding is fasting, inhibiting gastric acid secretion, protecting gastric mucosa, stopping bleeding, replenishing fluids and other treatments. 1. Fasting: for duodenal ulcer with upper gastrointestinal bleeding, fasting is the first step to avoid further aggravation of ulcer and bleeding. 2. Inhibit gastric acid secretion and protect gastric mucosa: acid-suppressing drugs mainly include proton pump inhibitors and H2 receptor antagonists, such as omeprazole and cimetidine. 3. Hemostasis: commonly used hemostatic drugs include sodium carisoprodol, tranexamic acid, etc. Yunnan Baiyao and other drugs can also be used. If the medication is not effective, endoscopic hemostasis can be used. 4. Rehydration therapy: when the bleeding volume is large, it is necessary to rehydrate in time to replenish blood volume and restore and maintain the perfusion of vital organs. The above drugs should be used under the guidance of specialized physicians. Duodenal ulcer with upper gastrointestinal bleeding should be actively treated to avoid life-threatening.