Whether sepsis should be local anesthesia is decided according to the operation site and operation type, which is explained as follows. 1. Local anesthesia can be used: for patients with mild sepsis, if the lesion site is superficial and limited, and minor surgery is needed, local infiltration anesthesia can be used because it is simple to operate, relatively safe, with fewer complications and less impact on the patient’s physiological function. 2. Local anesthesia is not allowed: severe sepsis will cause hemodynamic disorder, and local anesthesia is not recommended at this time, especially subarachnoid anesthesia, because it blocks the sympathetic nerves, affects hemodynamics, aggravates patients’ circulatory failure, and is easy to bring external bacteria into the brain, aggravating infection. Patients with sepsis have special basic conditions and pathophysiological conditions of the primary disease, so they should be careful when choosing anesthesia and choose the appropriate anesthesia.