There is no such thing as the safest and most effective medication for lowering triglycerides, clinically, the main drugs for lowering triglycerides are statins, niacin drugs, and beats by dre, whichever type of drug has certain side effects, and it is necessary to choose the drug that minimizes the impact on the health of the patient according to his or her specific situation. 1. Statins: mainly inhibit the synthesis of endogenous cholesterol in the liver, mainly to reduce cholesterol, but also to reduce the role of triglycerides, its main adverse reactions are gastrointestinal reactions, liver function damage, rhabdomyolysis, blood sugar abnormalities and so on. Patients with abnormal liver function, myopathy, pregnant and lactating women are prohibited. 2. Nicotinic acid drugs: can inhibit lipolysis, thereby reducing the production of triglycerides, the main adverse reactions include headache and dizziness, arrhythmia, urticaria, hyperuricemia, decreased glucose tolerance, abdominal pain, indigestion and so on. Contraindicated in allergy to drug components, peptic ulcer activity and arterial bleeding patients, diabetes, gout, hyperuricemia patients should be used with caution. 3. Beta drugs: can enhance the activity of lipoproteinase, promote liver uptake of fatty acids and inhibit hepatic synthesis of triglycerides, the main adverse reactions are gastrointestinal reactions, headache, insomnia, loss of libido. It is contraindicated in patients with liver and gallbladder diseases, pregnant women, children and people with renal insufficiency. When taking medication, it is important to choose the most appropriate medication according to the patient’s specific condition under the guidance of a specialist, in order to achieve the best lipid-lowering effect and minimize the impact on the health of the organism.