The cause of leg edema, a pit when pressed, is considered to be related to nephrotic syndrome, hypoproteinemia, heart failure and other factors, and diuretics, prednisone, highly branched chain amino acids and other medications can be given, and surgery can be performed if necessary. 1. Nephrotic syndrome: For patients with nephrotic syndrome, it may be due to glomerular injury, so it will cause intravascular fluid to accumulate in the interstitial space of the tissues, so there will be leg edema and a crater when pressed. Diuretic drugs can be given to increase the fluid output of the kidneys, such as etanercept and mannitol, etc., to reduce the phenomenon of edema in patients. At the same time, glucocorticoids such as prednisone need to be used, which can play an anti-inflammatory role and reduce the exudation of the acute inflammatory phase. 2. Hypoproteinemia: patients with hypoproteinemia, plasma albumin will be reduced, the body’s effective osmotic pressure is reduced, will make the tissue retention of excessive water, causing patients with leg edema a press a pit symptom, can be supplemented with high-branched-chain amino acid drugs, improve serum albumin levels, improve the patient’s symptoms. 3. Heart failure: heart failure patients, often because of the reduction of renal blood flow and oliguria, and then produce legs and feet edema, a press a pit symptoms, in the acute stage, the need to consult the doctor as soon as possible for rescue, stable stage, with the doctor to give etanercept and other diuretic drugs to reduce the burden on the patient’s heart, and, if necessary, choose the way of cardiac transplantation intervention therapy. It is recommended that the patient can go to the hospital to clarify the cause of leg edema, and follow the doctor’s instructions for treatment, so as not to delay the condition.