Shingles does not usually lead to death, but in the case of disseminated shingles, which invades organs such as the lungs and brain, it can be severe enough to cause death in humans. Herpes zoster is caused by varicella zoster virus infection and is an acute infectious skin disease. The body’s immunity is lowered and the varicella zoster virus lurks in the ganglia, which can trigger shingles if reactivated. Development may result in erythema, papules, and clusters of blisters on one side of the body, and the pain may be more intense in older, weaker patients. There is also the possibility of ocular shingles, ear shingles, tonic shingles, and rashless shingles. If it violates the central nervous system, it can cause viral meningitis and meningitis. Invasion of visceral nerves can cause cystitis, acute gastroenteritis. In patients with malignant tumors or in the elderly and infirm, herpes zoster virus spreads through the bloodstream and can lead to an extensive varicella-like rash. If it invades the lungs, brain and other organs, it may lead to death of the patient in severe cases. The appearance of blisters on the skin with neuralgia, need to promptly go to the hospital, follow the doctor’s instructions for treatment, do not do it yourself.