Megasplenism does not cause a dramatic increase in white blood cells; an enlarged spleen destroys white blood cells instead.
There are many causes of enlarged spleen, which are categorized into infectious and non-infectious splenomegaly. Infectious spleens are mostly caused by acute and chronic infections, such as malaria and EBV infections; non-infectious spleens are bruised spleens, connective tissue disorders, splenic tumors, blood disorders, and lipid deposition disorders.
If the giant spleen is accompanied by a markedly elevated white blood cell, then there is a high degree of suspicion for myeloproliferative disorders in hematologic diseases, such as myelofibrosis, chronic granulocytic leukemia, chronic granulomonocytic leukemia, and so on.
If there is a huge spleen or significantly elevated white blood cells, it is recommended to go to the hospital for a comprehensive examination to clarify the cause. Pay attention to the regularity of work and rest, eat a light diet, appropriate exercise, and maintain a relaxed mood. Specific disease diagnosis needs to be carried out under the guidance of a physician.