Alprazolam and eszopiclone both belong to the benzodiazepine class of drugs, and the side effects of the two drugs are basically similar without much difference, with some emphasis in clinical application. Alprazolam is mainly used in the treatment of anxiety-related disorders in clinical practice, with the potential advantage of a rapid onset of action and a weaker sedative effect compared to other benzodiazepines. Common adverse effects include drowsiness, dizziness, and fatigue. There are addictive properties, and withdrawal symptoms may occur with discontinuation of the drug after prolonged application, manifesting as agitation or depression. It is contraindicated for those who are allergic to the product and the ingredients contained in it, those with hepatic or renal impairment, patients with myasthenia gravis, and patients with acute or easy-to-occur closed-angle glaucoma. Eszopiclone is mainly used for the treatment of sleep disorders in the clinic, because of its half-life of 10~24 hours, mainly used for the treatment of insomnia patients who wake up in the middle of the night or wake up early. It can increase the total sleep time and reduce the number of nighttime awakenings. Adverse reactions include dry mouth, drowsiness, dizziness, and fatigue. There is dependence, but it is mild, and withdrawal symptoms may occur with discontinuation of the drug after prolonged application, manifesting as agitation or depression. It is contraindicated in people who are allergic to the product and the ingredients contained in it, people with hepatic or renal impairment, patients with myasthenia gravis, and patients with acute or easy-to-occur closed-angle glaucoma. Alprazolam and Eszopiclone are both psychotropic class II drugs and need to be taken under the guidance of a physician, do not take the drug on your own.