Hypodense foci in the left lobe of the liver indicate a lesion in the left lobe of the liver, which is most often benign or malignant in nature. Hepatic space-occupying lesions must be alerted to the possibility of malignancy, and in conjunction with the patient’s past medical history, if there is a history of hepatitis and neoplasia, enhancement CT or MRI must be performed. There is enhancement after enhancement under imaging, especially single hypoechoic mass in the liver, which can be punctured or surgically resected if necessary, and pathologic examination can be performed for clarification. If the patient has symptoms of hyperlipidemia, fatty infiltration cannot be excluded, and this fatty infiltration has no enhancement on imaging and requires lipid-lowering therapy. Some low-density foci in the left lobe of the liver are considered to be atypical hemangiomas and liver abscesses as well as misshapen tumors, which need to be clarified by a combination of various examinations.