The common causes of high total bilirubin and unconjugated bilirubin are overproduction of bilirubin and decreased hepatic conjugation capacity, which can be seen in hemolysis, cirrhosis, Gilbert’s syndrome and so on. 1. Excessive production of bilirubin: e.g. intravascular and extravascular hemolysis, absorption of large hematoma, neonatal jaundice, transfusion of incompatible blood groups. 2. Decrease in hepatic binding capacity: such as hepatitis, cirrhosis, etc., the liver’s uptake of unconjugated bilirubin conversion capacity is reduced; some inborn genetic metabolic diseases, such as Gilbert’s syndrome, there is a lack of certain enzymes in the cell or a decrease in the number of these conditions may be elevated total bilirubin and unconjugated bilirubin. There may be other reasons for high total bilirubin and unconjugated bilirubin, so it is recommended to consult a doctor in time, complete the relevant examinations to clarify the cause of the disease and then carry out targeted treatment to avoid adverse consequences.