The management of slightly high direct bilirubin and normal aminotransferases needs to take into account the cause of the disease and formulate corresponding management measures. These include dietary modification, medication (e.g. hepatoprotective tablets, entecavir), further examination, and surgical treatment. The causes of this condition include diet and disease, and common diseases include bile duct stones, biliary tract tumors, viral hepatitis and so on. 1. Lifestyle and dietary causes and treatment: tiredness, late night, drinking and other reasons can lead to this condition, generally adjust the lifestyle and diet can be regularly reviewed. 2. Disease causes and treatment: can be combined with blood routine, liver and gallbladder ultrasound, viral series and other clear. (1) If the bile duct stones need to consider endoscopic treatment, cholecystectomy and so on; (2) If accompanied by biliary tract infection, antibiotic treatment should be selected according to sensitive bacteria; (3) If biliary tract tumor needs to consider surgical treatment; (4) If viral hepatitis, drugs such as entecavir and tenofovir should be considered; (5) If the drug liver damage can be given to protect the liver tablets, glutathione tablets and other drugs. For the case of direct bilirubin slightly high transaminases normal, it is recommended to consult the doctor to develop individualized treatment measures according to the situation.