Most of the 5 year old babies who cough a lot at night are related to pneumonia, cough variant asthma, upper respiratory cough syndrome, and gastroesophageal reflux. Babies are prone to cough at night, most of them are due to mycoplasma infections or allergies induced by the factors of bronchitis pneumonia. Sputum blockage of the trachea or allergic substances to stimulate tracheal spasm caused by coughing, to take a timely film as well as to do the mycoplasma nucleic acid PCR or mycoplasma antibody titer test, if the Mycoplasma pneumoniae infection, can be preferred to azithromycin treatment. Upper respiratory cough syndrome in the postural change, nasal secretions from the postnasal flow to the pharynx caused by severe cough, should be actively treating the primary disease, improve nasal ventilation, etc.. Such as cough variant asthma, gastroesophageal reflux and other diseases can also lead to the baby cough in the middle of the night obvious, can be under the guidance of the doctor to improve the lung function, gastroscopy, 24 hours of esophageal PH monitoring and other related tests to assist in the diagnosis. If necessary, follow the doctor’s instructions for treatment.