It is possible to make mistakes in biopsy, but the chance is very low. Biopsy is a kind of pathology examination commonly used in clinic to take biopsy tissue from lesion site or suspicious site for examination, in order to clarify the diagnosis of the disease, etiology and extent of the lesion and to judge the benign or malignant nature of the tumor, so as to formulate a good treatment plan according to the extent of the disease. Depending on the location of the lesion, clamping, scraping, excision, coarse needle puncture and other methods can be used to obtain tissues from the biopsy and send them to pathology for examination according to strict procedures. The accuracy of biopsy can reach more than 90%, biopsy may be wrong, but the chance is very low, which may be related to the sampling site and the diagnostic level of the diagnostic pathologist and other factors, but generally is rarely missed. If the patient’s clinical diagnosis does not match with the pathological findings, it is recommended to go to a higher level hospital for another review to avoid misdiagnosis and delay. Adults are advised to have regular health checkups once a year, strengthen exercise, and eat more vegetables and fruits to enhance resistance. When there is any discomfort in the body, it is time to consult a doctor in time for examination and treatment under the guidance of a professional doctor.