High prolactin and low progesterone may be caused by luteal insufficiency, prolactin-type pituitary microadenomas, etc., which can be treated by surgery and drugs. Luteinization is the secretion of progesterone, luteal insufficiency is mostly due to poor follicular development, the luteinization will atrophy very early after ovulation, so this time progesterone will be significantly lower, lower progesterone will not be able to maintain the normal development of the fetus, it is very likely that the phenomenon of miscarriage will occur, to comply with the doctor’s instructions in time to take oral progesterone to carry on the treatment. Prolactin is secreted by the pituitary gland, prolactin increase, the most common cause is prolactin-type pituitary microadenoma, need to be examined through the pituitary MRI scanning plus enhancement scanning, if the pituitary microadenoma is detected, neuroendoscopic surgical treatment can be considered, if the pituitary microadenoma is not detected, it is a hyperprolactinemia, bromocriptine can be selected for oral treatment. Patients with high prolactin and low progesterone are advised to go to the hospital in time for examination to clarify the cause, and if necessary, take medication under the guidance of the doctor for treatment, pay attention to rest, maintain a good state of mind, and undergo regular review.