The treatments for keratinized squamous cell carcinoma of tongue include surgery, radiation therapy, chemotherapy and biological therapy. 1. Surgical treatment: it can be divided into removing the lesion through surgery, cleaning the lymph nodes and repairing the defective part of tongue. The treatment plan should be decided according to the shape, size and location of the tumor, imaging results and the patient’s physical condition. 2. Radiation therapy and chemotherapy: it is the treatment method to assist surgery after operation, and the commonly used chemotherapy drugs include cisplatin and so on. 3. Biological therapy: mainly for patients with advanced recurrence and metastasis of cancer, as well as those who do not have surgical conditions. Such as applying immunotherapy of PD-1/PD-L1 monoclonal antibody, using interferon therapy and other methods for auxiliary anti-tumor therapy. In case of early keratinizing squamous cell carcinoma of the tongue, monoclonal antibodies and tumor growth inhibitors can be used to treat the tumor. The treatment methods for keratinizing squamous cell carcinoma of tongue need to be chosen under the professional advice of doctors. If you feel unwell, you should go to regular hospitals for medical treatment in time so as not to delay the diagnosis and treatment of the disease.