Nucleic acid test generally refers to neocoronavirus nucleic acid test, and taking cold medicine has no effect on nucleic acid test. According to the “New Coronavirus Pneumonia Diagnosis and Treatment Program (Trial Ninth Edition)”, nucleic acid test is still the gold standard for diagnosing new coronavirus pneumonia. The new crown nucleic acid test is mainly performed by examining the patient’s respiratory secretions through nasal swabs or throat swabs to clarify the presence of nucleic acid of the new coronavirus, i.e., the gene fragment specific to the new coronavirus. If the gene fragment is present, the test is positive. Cold remedies are medicines used to relieve the symptoms of colds and flu, which do not destroy the gene fragment unique to the novel coronavirus, and therefore do not affect the nucleic acid test. In the context of the normalization of epidemic prevention and control, it is not recommended to use cold medicines on one’s own when “cold” symptoms such as cough or fever occur, but to go to the hospital for timely consultation, screening and examination to rule out the possibility of neocoronavirus infection. In addition, during the period of high incidence of the spread of new coronavirus, we need to strengthen personal protection, including wearing a good mask when going out and washing hands in a timely manner after returning home. Tips] In this article, the terms “new coronavirus pneumonia” and “new coronavirus pneumonia” have been renamed to “new coronavirus infection” on December 26, 2022, as announced by the National Health Commission.