The presence of a foreign body sensation at the base of the tongue may be associated with diseases such as chronic pharyngitis and tongue cancer. It is mainly treated by drugs and surgery. 1. Chronic pharyngitis mainly refers to diffuse inflammation of the mucosa, submucosa and lymphatic tissues of the pharynx. Typical symptoms are itching sensation or foreign body sensation in the pharynx, which is mainly related to the proliferation of lingual tonsils and pharyngeal follicles. Common treatment drugs include amoxicillin and metronidazole. 2. Tongue cancer is a common malignant tumor in the oral cavity, and early stage may show thickening of mucosal tissues and small hard nodules, which will lead to foreign body sensation and discomfort at the root of tongue. It is usually treated by surgery with selective cervical lymph node dissection. Common therapeutic drugs include pingyangmycin and cisplatin. If you find a foreign body sensation in the root of the tongue, you should seek medical treatment in time and under the guidance of the doctor, do not take medication without authorization, so as not to delay the condition. Pay attention to oral hygiene care on weekdays, quit smoking and drinking, eat less spicy food, and maintain a regular routine.