The main efficacy of Mesylate and Propafenone is the same, both for antiarrhythmia, but the indications are different, specific instructions for use. Propafenone belongs to class Ic antiarrhythmic drugs, applicable to paroxysmal ventricular and supraventricular tachycardia (including with pre-excitation syndrome). Dry mouth and numbness of the tongue and lips are the main adverse effects of the drug. Contraindications include hypersensitivity to the product, patients with bifascicular block, severe atrioventricular block, sinus node dysfunction without pacemaker protection, severe hypotension or congestive heart failure, and cardiogenic shock. Mesylate belongs to class Ib antiarrhythmics, and the oral formulation is mainly used for the treatment of chronic ventricular arrhythmias such as ventricular premature exposures and ventricular tachycardia. Contraindications to the use of the drug include those with sick sinus syndrome, cardiogenic shock, and those with degree II or III atrioventricular block. The most common adverse reactions include nausea, vomiting, dizziness, tremor, nystagmus, ataxia, and somnolence. Both of the above drugs belong to the anti-arrhythmic drugs, the efficacy is basically the same, but the specific type of different, slightly different indications for use. The specific use of drugs should be carried out under the guidance of a specialist physician, do not unauthorized use of drugs.