Patients with HIV will develop chronic diarrhea, and the first step in the treatment of chronic diarrhea is to administer antiviral therapy to patients with HIV. Antiviral therapy is usually a combination therapy. After a period of antiviral therapy, the virus is suppressed and some patients’ diarrhea will improve. There is also treatment for the cause of the diarrhea, if the diarrhea is caused by a bacterial infection, anti-infective treatment is needed; if the diarrhea is caused by a viral infection, antiviral drugs may be needed. There is also treatment related to the symptoms. If the number of diarrhea is high and the amount of diarrhea is large, appropriate rehydration is needed, either orally or intravenously, anti-diarrheal medications can be used, and if necessary, oral medications to regulate intestinal flora can be taken, etc.