Lax connective tissue cells have no polarity. Polarity refers to the fact that different surfaces of a cell have distinct differences in structure and function. The cells within the loose connective tissue are: undifferentiated mesenchymal cells, fibroblasts, adipocytes, macrophages, plasma cells, mast cells and leukocytes among others. First of all, macrophages, plasma cells, mast cells and leukocytes as immune cells, the different surfaces of the cells have the same function, so they do not have polarity. Adipocytes and fibroblasts as cells that fill in the mesenchyme, the different surfaces of the cells also have the same function and are not polarized. Undifferentiated mesenchymal cells retain their multidirectional differentiation potential and are also not polarized. Any associated discomfort requires medical attention as soon as possible and treatment under medical supervision.