The 13-valent pneumonia vaccine is effective for a minimum of 5 years. The 13-valent Pneumonia Vaccine (PVP) has a minimum duration of validity of 5 years and is effective in preventing pneumonia in children against invasive disease caused by Streptococcus pneumoniae serotypes 1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F, and 23F. The shorter protection period of the 13-valent pneumonia vaccine is mainly due to its short lifespan in inducing lymphocyte production and memory lymphocytes. If a child is more immunocompromised, a catch-up vaccination five years after the first 13-valent pneumococcal vaccine is required to maintain its expiration date. However, the ability to receive the pneumonia vaccine is subject to the advice of a doctor. If there are any adverse reactions, it is important to seek prompt medical attention to avoid adverse consequences.